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Release Date: September 16, 2010
Opening Date: October 5, 2010 (Earliest date an application may be submitted to Grants.gov).
Letter of Intent Receipt Date(s):, February 8, 2011, June 6, 2011, October 10, 2011, February 6, 2012, June 6, 2012, October 8, 2012, February 8, 2013, June 10, 2013, October 8, 2013..
Application Receipt Date(s):, March 8, 2011, July 6, 2011, November 10, 2011, March 6, 2012, July 6, 2012, November 8, 2012, March 8, 2013, July 10, 2013, November 8, 2013.
Peer Review Date(s): February/March 2011, June/July 2011, September/October 2011, February/March 2012, June/July 2012, September/October 2012, February/March 2013, June/July 2013, September/October 2013.
Council Review Date(s): August 2011, October 2011, January 2012, August 2012, October 2012, January 2013, August 2013, October 2013, January 2014.
Earliest Anticipated Start Date(s): September 2011, December 2011, April 2012, September 2012, December 2012, April 2013, September 2013, December 2013, April 2014.
Additional Information: To Be Available Date (URL Activation Date): Not applicable
Expiration Date: November 9, 2013

Funding Opportunity Description

Purpose

This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), invites grant applications to provide targeted infrastructure support for the core functions of Cancer Epidemiology Cohorts (CECs) and methodological research. This infrastructure can serve either the continuation of an existing CEC or the establishment of a new CEC. This FOA will support core functions for CECs currently funded through other grant mechanisms. This FOA must be used for all requests for support to continue existing CECs or to establish new CECs.

Background

Classic CECs are organized for large observational human population studies in which groups of people with a set of characteristics or exposures are followed systematically and prospectively for the incidence of new cancers, cancer mortality, and/or cancer-related outcomes. This definition includes large cohorts of cancer patients in observational studies involving responses to therapies and short- and long-term health outcomes occurring after diagnosis. Throughout the last two decades, CEC-based studies have helped to better understand the complex etiology of cancer and have provided fundamental insights into key environmental, lifestyle, and genetic determinants of this disease. Findings from CECs are critical for risk prediction analyses and models. These findings may also serve as a basis for cancer control measures for groups and populations at risk. Evidence generated by CECs has also been useful in providing the basis for the design and testing of many preventive and therapeutic interventions. Large biorepositories established by CECs already support genomic and epigenetic studies, and are beginning to support proteomic and metabolomic studies. Further, CECs are essential to genome-wide association studies (GWAS) and replication and/or expansion of prior GWAS findings) that has led and will lead to the identification of putative cancer susceptibility loci of low penetrance and high frequency, and will potentially lead to the identification of genes associated with prognosis and survival for a variety of cancers. As the genes present in these loci are identified and their functions are clarified, the prospective exposure data accumulated from CECs afford opportunities for in-depth analyses of gene-environment interactions, which will be critical for the design of public health interventions. NCI recognizes that CECs are valuable resources that benefit the entire cancer research community and, that in order to be successful as a population sciences research resource, CECs need to accrue large and varied population samples and continue to follow-up with study participants over an extended period of time.

Eligible Applicants

State governments
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)

Additional Information on Eligibility:

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Agency Name

National Institutes of Health